CSIR | GATE | NEET | Medical | Life Sciences | XL | Biochemistry | MCQs - 004

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Q.004: Which one of the enzymes is responsible for arsenic toxicity?

a) Pyruvate kinase

b) Aldolase

c) Phosphofructokinase

d) Pyruvate dehydrogenase


Ans. d

Pyruvate dehydrogenase - this enzyme complex catalyzes the conversion of pyruvate to acetyl CoA. It is an example of a large multienzyme complex in which reaction intermediates are passed directly from one enzyme to another. The complex converts pyruvate to acetyl CoA in the mitochondrial matrix; NADH is also produced in this reaction.

Trivalent inorganic arsenic inhibits pyruvate dehydrogenase by binding to the sulfydryl groups of dihydrolipoamide, resulting in a reduced conversion of pyruvate to acetyl coenzyme A (CoA), so that both the citric acid cycle activity and production of cellular ATP are decreased.


source: https://www.sciencedirect.com/


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