CSIR | GATE | NEET | Medical | Life Sciences | XL | Biochemistry | MCQs | 006

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Q.006: The sodium-independent iodide/chloride transporter is named as

a. megalin

b. pendrin

c. transthyretin

d. prestin



Ans: b - pendrin

Pendrin is an anion transporter encoded by the PDS/Pds gene. In humans, mutations in PDS cause the genetic disorder Pendred syndrome, which is associated with deafness and goiter.

Pendrin is an anion exchange protein that in humans is encoded by the SLC26A4 gene (solute carrier family 26, member 4). Pendrin was initially identified as a sodium-independent chloride-iodide exchanger with subsequent studies showing that it also accepts formate and bicarbonate as substrates.

Pendrin is responsible for mediating the electroneutral exchange of chloride (Cl−) for bicarbonate (HCO3−) across a plasma membrane in the chloride cells of freshwater fish.

 

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